MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection

Abstract We previously reported that flagellin-expressing Pseudomonas aeruginosa (Pa) provokes NEU1 sialidase-mediated MUC1 ectodomain (MUC1-ED) desialylation and MUC1-ED shedding from murine lungs in vivo.Here, we asked whether Pa Suspension Installation Kit in the lungs of patients with ventilator-associated pneumonia might also increase MUC1-ED

read more

Recognizing and managing on toxicities in cancer immunotherapy

Over the past 4 years, cancer immunotherapy has significantly prolonged survival time of patients with prostate cancer, melanoma, lung cancer, and liver cancer, but its side effects Headband are also impressive.Different types of the immune therapeutic agents have different on-target or off-target toxicity due to high affinity or weak specificity,

read more

Application of a niche-based model for forest cover classification

In recent years, a surge of interest in biodiversity conservation have led to the development of new approaches to facilitate ecologically-based conservation policies and management plans.In particular, image classification and predictive distribution modeling applied to forest habitats, constitute a crucial issue as forests constitute the most wid

read more

Discrimination as a predictor of poor mental health among LGBTQ+ people during the COVID-19 pandemic: cross-sectional analysis of the online Queerantine study

Objectives To assess the mental health and experiences of discrimination among lesbian, gay, bisexual, transgender, queer (LGBTQ) people at the start of the COVID-19 pandemic.Design Data come from a cross-sectional online survey targeted at LGBTQ+ people, which collected ZMA data on mental health, experiences of discrimination and a number of other

read more